Extra individuals are starting to open up about utilizing new-generation weight-loss and diabetes drugs like Mounjaro (tirzepatide).
Just lately, filmmaker Hansal Mehta shared a submit on X about his expertise with the drug, pairing it with main way of life adjustments to deal with prediabetes and weight achieve. “Below medical steering, I started Mounjaro to deal with rising blood sugar ranges within the pre-diabetic vary and to handle my steadily growing weight. Paired with a dedicated way of life shift — high-protein meals, minimal sugar and alcohol, common energy coaching, correct hydration, 14-18 hour intermittent fasting, NMN + Resveratrol dietary supplements, and higher sleep — I’ve seen tangible outcomes,” Mehta wrote. “In only a few months, I’m down almost 10 kilos. My muscle mass has considerably improved, my power ranges are increased, and my blood sugar readings at the moment are nicely throughout the regular vary. Insulin resistance has dropped, and sure, the outdated garments are falling off!”
He added that he’s sharing his story “as a result of there’s pointless stigma round these new drugs and individuals who do use them falsely join their newfound well being to ambiguous and sometimes irritating health regimens.” “There’s no disgrace in taking cost of your well being with the instruments out there to you—particularly when accomplished responsibly and underneath supervision. If you happen to’re battling comparable points, communicate to your healthcare supplier. It’d simply be the start of a journey you’ll be thankful for,” he continued.
How does Mounjaro work to enhance each blood sugar management and weight reduction, and why would possibly it’s particularly efficient when mixed with weight loss plan and train?
Dr Kalyan Kumar Gangopadhyay, endocrinologist, CMRI Kolkata, tells indianexpress.com, “After we eat, our physique releases many hormones—two of the essential ones are GLP-1 and GIP. These hormones assist enhance insulin ranges, which in flip deliver down blood sugar after a meal. Mounjaro combines each these actions. So when somebody takes it, it mimics these pure hormones, serving to the physique launch extra insulin and decreasing blood sugar ranges — however solely when wanted. It doesn’t trigger sugar ranges to drop in the event that they’re already regular, so the probabilities of hypoglycemia are low.”
One other essential factor is that these similar hormones act on the a part of the mind that controls starvation and satiety, Dr Gangopadhyay notes. He provides, “So individuals really feel full with smaller parts and have a tendency to eat much less general, which helps weight reduction.”
Below medical steering, I started Mounjaro to deal with rising blood sugar ranges within the pre-diabetic vary and to handle my steadily growing weight. Paired with a dedicated way of life shift—high-protein meals, minimal sugar and alcohol, common energy coaching, correct hydration,… pic.twitter.com/R0GnHuEcl7
— Hansal Mehta (@mehtahansal) May 1, 2025
Dr Namgyal, MBBS, MD, diabetologist AIIMS New Delhi, shares, “Medicine alone shouldn’t be an entire resolution. When mixed with a balanced weight loss plan and constant bodily exercise, the consequences of Mounjaro may be amplified. Life-style adjustments assist enhance metabolic well being, protect muscle mass, and assist long-term weight administration.”
Can Mounjaro contribute to lowered insulin resistance and improved muscle mass?
Dr Gangopadhyay mentions, “Sure, Mounjaro will help scale back insulin resistance, each immediately and not directly. One of many key methods it does that is by serving to with weight reduction, which itself makes the physique extra attentive to insulin. When somebody is insulin resistant, their physique isn’t utilizing insulin successfully. Losing a few pounds tends to enhance that, and Mounjaro helps this course of.”
Concurring, Dr Namgyal explains that enhancements in muscle mass are usually related to way of life components, significantly resistance coaching and satisfactory protein consumption. “The medicine can set the stage by bettering metabolic effectivity and supporting weight reduction, however preserving or growing muscle mass requires intentional effort.”
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Security, potential negative effects, and long-term sustainability of utilizing drugs like Mounjaro
In line with Dr Gangopadhyay, it’s essential to know that Mounjaro is a comparatively new drug. “We at present have knowledge for as much as about two years of use. Which means we’re nonetheless studying about its long-term results. What we do know to this point is that the load loss it helps obtain tends to reverse step by step as soon as the medicine is stopped.”
Dr Namgyal says that Mounjaro shouldn’t be a one-size-fits-all resolution. “Unwanted effects like nausea, vomiting, constipation, and urge for food suppression are comparatively frequent within the preliminary levels. In uncommon instances, extra severe issues might come up, particularly in people with sure pre-existing circumstances.”
That stated, Dr Gangopadhyay confirms most individuals don’t have to cease the medicine due to these points, and signs typically settle with time. “Nonetheless, this medicine isn’t suggested for individuals with a historical past of pancreatitis, and it hasn’t been studied in sufferers with superior diabetic eye illness, so warning is critical in these instances.”
DISCLAIMER: This text relies on info from the general public area and/or the consultants we spoke to. All the time seek the advice of your well being practitioner earlier than beginning any routine.