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Home»Health»Male birth-control, Humana lawsuit, and more
Health

Male birth-control, Humana lawsuit, and more

December 13, 2023No Comments6 Mins Read
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Perceive how science, well being coverage, and medication form the world on a regular basis. Join our Morning Rounds publication right here.

Good morning. Don’t miss Brittany Trang’s compelling story about seven-year-old Shelby Campbell’s life — and her household’s — whereas being handled for beta thalassemia with gene remedy.

What ‘one time’ means once you’re 7 years previous and gene remedy takes a grueling yr

Shelby and her dad and mom sit collectively for household pancake breakfast on Saturday morning at residence in Mechanicsburg, PA on August 26, 2023. Amanda Berg for STAT

Two gene therapies authorised by the FDA final week have been heralded as one-time, primarily healing therapies. However what does that imply? To depart behind beta thalassemia or sickle cell illness, “one time” means months, or for seven-year-old Shelby Campbell, multiple yr. That features seven weeks within the hospital, poisonous chemotherapy to wipe out faulty cells, hair loss, excessive fevers and mouth sores, and isolation from buddies and college.

STAT’s Brittany Trang chronicled the Campbell household’s journey by means of Shelby’s therapy for beta thalassemia with Bluebird Bio’s Zynteglo. “It’s positively not a fast repair or a straightforward repair,” mentioned her mom, Michelle Campbell. But by the tip, Shelby was giving recommendation to a different little one about feeding-tube insertion: “You would possibly must get it in a number of occasions however when you get used to it, it’s not that scary and you realize what to anticipate.” Learn extra.

Humana sued once more over algorithm used to disclaim care

A second class motion lawsuit from Medicare Benefit beneficiaries was filed yesterday towards Humana, additionally alleging that the medical health insurance large used an algorithm to chop off cost for rehabilitative care wanted by sufferers recovering from critical sicknesses and accidents. This one, filed in U.S. District Courtroom in Western Kentucky, argues Humana’s reliance on the algorithm was a part of a fraudulent scheme to reap a windfall by systematically denying claims to desperately sick folks. An earlier grievance was filed in November towards the algorithm’s maker, NaviHealth, and its proprietor, UnitedHealth Group.

Each fits observe a STAT investigation that discovered Medicare Benefit insurers nationwide are utilizing the algorithm to chop off sufferers’ rehab care. Complaints alleging the improper denial of care are widespread, STAT’s Bob Herman and Casey Ross level out, however these instances are among the many first to problem insurers’ reliance on an inside algorithm. Learn extra.

Promising information about an under-the-radar sickle cell therapy

Historic approvals of two dear ($2.2 million and $3.1 million) gene therapies for sickle cell illness have grabbed our consideration, however there’s a cheaper, extra conventional strategy turning heads on the American Society of Hematology in San Diego. Yesterday scientists reported advances in bone marrow transplantation, a decades-old strategy meaning sufferers want a well-matched donor and a hearty dose of chemotherapy, two necessities exhausting for many sufferers to fulfill.

Within the new mid-stage trial, after sickle cell sufferers got a gentler course of chemo and an infusion of half-matched cells, that they had much less ache, 95% have been alive two years after transplant, and solely 7% skilled a extreme immune response, research co-author Adetola Kassim informed reporters. “No matter we do by way of novel analysis, if it can’t attain the sufferers who want it, what’s the entire thought?” research co-author Adetola Kassim mentioned. STAT’s Jonathan Wosen has extra. And STAT’s Jason Mast studies on about early animal information from Novartis introduced on the similar assembly a few potential capsule for the illness.

Docs name out ableism in most cancers care, the place assumption can hurt sufferers

Cheri Blauwet (right) with a patient in an exam room. -- health coverage from STAT
Spaulding Rehabilitation Community

Individuals who have a incapacity usually want to teach others about what they will and may’t do, together with docs whose assumptions can undermine their care. In most cancers, for instance, clinicians would possibly assume a lady who makes use of a wheelchair isn’t sexually lively, so doesn’t should be examined for the virus that causes cervical most cancers. After a most cancers prognosis, therapy can observe outdated determination timber that rely on a affected person’s skill to stroll as a benchmark for tolerating chemotherapy.

“To make an assumption {that a} wheelchair consumer should inherently be somebody with a major burden of continual illness is a really ableist assumption,” Cheri Blauwet, chief medical officer at Spaulding Rehabilitation Hospital (pictured above with David Estrada), informed me. It’s maybe an understatement to say she is aware of whereof she speaks. She’s a Paralympic gold medalist and two-time winner of each the Boston Marathon and the New York Metropolis Marathon in wheelchair racing. I’ve extra right here.

For teenagers with excessive BMI, process power not able to advocate weight reduction medication

In its new draft advice on excessive BMI in youngsters and adolescents, the U.S. Preventive Providers Activity Pressure has moved from its 2017 steering suggesting screening to urging intensive, complete behavioral interventions. As we speak’s suggestions, open for remark till Jan. 16, cease in need of weight-loss drugs for the roughly 20% of youngsters and youths with excessive BMI within the U.S., saying “extra analysis is required to totally perceive the long-term well being outcomes for drugs.”

As an alternative, the group recommends offering or referring youngsters age 6 and older who’ve a BMI above the ninety fifth percentile for age and intercourse on the expansion chart to behavioral interventions equivalent to supervised train, counseling for habits change, and details about wholesome consuming. The American Academy of Pediatrics has come out in favor of weight-loss medication for adolescents, however as this New York Instances story tells us, many pediatricians are reluctant to prescribe them.

Experimental male birth-control capsule enters trial

We haven’t heard an excessive amount of recently about male contraception, however a San Francisco startup hopes to vary that story with a non-hormonal drug candidate that started its Part 1 scientific trial right this moment within the U.Ok. to check the security, tolerability, and functioning of the oral drug in 16 contributors. YourChoice Therapeutics is betting on century-old science that found mice, rats, and monkeys with vitamin A deficiency have been infertile, which dozens of papers have since confirmed. The experimental drug is designed to cease the metabolism of vitamin A within the testicles, thus blocking each the manufacturing and the discharge of sperm — fully eliminating the probabilities of fertilizing an egg.

In the end, the workforce behind YCT-529 hopes that if their product is profitable, it’d assist change the dynamics of contraception, and make it extra of a shared duty. STAT’s Annalisa Merelli has extra, together with one other male contraceptive product at the moment being studied.

What we’re studying

  • Pharmacies share medical information with police with no warrant, inquiry finds, Washington Put up

  • CPR will be lifesaving for some, futile for others. Right here’s what makes the distinction, NPR
  • A focused remedy reveals it might supply a ‘final, nice probability’ for some acute leukemia sufferers, STAT
  • 1000’s of sufferers could also be present process vascular procedures too quickly or unnecessarily, ProPublica
  • Maze CEO ‘personally disillusioned’ in Sanofi determination to terminate partnership, STAT



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